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International Journal of Alzheimer’s Disease
Volume 2012 (2012), Article ID 251426, 13 pages
Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease
Experimental Genetics Group (LEGTEGG), Department of Human Genetics, KU Leuven, Campus Gasthuisberg ON1-06.602, Herestraat 49, 3000 Leuven, Belgium
Received 14 February 2012; Accepted 16 March 2012
Academic Editor: Rakez Kayed
Copyright © 2012 Natalia Crespo-Biel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [21 citations]
The following is the list of published articles that have cited the current article.
- Clara Theunis, Natalia Crespo-Biel, Valerie Gafner, Maria Pihlgren, Maria Pilar Lopez-Deber, Pedro Reis, David T. Hickman, Oskar Adolfsson, Nathalie Chuard, Dorin Mlaki Ndao, Peter Borghgraef, Herman Devijver, Fred Van Leuven, Andrea Pfeifer, and Andreas Muhs, “Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy,” Plos One, vol. 8, no. 8, 2013.
- Qiu-Yan Liu, Jin-Tai Yu, Dan Miao, Xiao-Ying Ma, Hui-Fu Wang, Wei Wang, and Lan Tan, “An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease,” Neurobiology of Aging, vol. 34, no. 5, pp. 1519.e13–1519.e17, 2013.
- Wenjia Lai, Jing Wu, Xiao Zou, Jian Xie, Liwei Zhang, Xuyang Zhao, Minzhi Zhao, Qingsong Wang, and Jianguo Ji, “Secretome Analyses of A beta(1-42) Stimulated Hippocampal Astrocytes Reveal that CXCL10 is Involved in Astrocyte Migration,” Journal Of Proteome Research, vol. 12, no. 2, pp. 832–843, 2013.
- Pu Fang, Wenyuan Xu, Chengsi Wu, Min Zhu, Xiaobing Li, and Daojun Hong, “MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population,” Neural Regeneration Research, vol. 8, no. 33, pp. 3116–3123, 2013.
- Manjinder Singh, Maninder Kaur, Hitesh Kukreja, Rajan Chugh, Om Silakari, and Dhandeep Singh, “Acetylcholinestrase Inhibitors as Alzheimer Therapy: From Nerve Toxins to Neuroprotection,” European Journal of Medicinal Chemistry, 2013.
- Wolfgang Froestl, Andrea Pfeifer, and Andreas Muhs, “Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs,” Journal Of Alzheimers Disease, vol. 34, no. 1, pp. 1–114, 2013.
- Pradip K. Kamat, Chandishwar Nath, and Shivika Rai, “Okadaic acid induced neurotoxicity: An emerging tool to study Alzheimer's disease pathology,” Neurotoxicology, vol. 37, pp. 163–172, 2013.
- Bruno Bulic, Marcus Pickhardt, and Eckhard Mandelkow, “Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease,” Journal Of Medicinal Chemistry, vol. 56, no. 11, pp. 4135–4155, 2013.
- Benoît Leclerc, and Abedelnasser Abulrob, “Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease,” The Scientific World Journal, vol. 2013, pp. 1–16, 2013.
- Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Herve Maurin, and Fred Van Leuven, “Phosphorylation of protein Tau by GSK3 beta prolongs survival of bigenic Tau.P301L x GSK3 beta mice by delaying brainstem tauopathy,” Neurobiology of Disease, vol. 67, pp. 119–132, 2014.
- Mansour Akbari, Guido Keijzers, Scott Maynard, Morten Scheibye-Knudsen, Claus Desler, Ian D. Hickson, and Vilhelm A. Bohr, “Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair,” Dna Repair, vol. 16, pp. 44–53, 2014.
- Hervé Maurin, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, and Fred Van Leuven, “Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β,” European Journal of Neuroscience, 2014.
- Herve Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Claire Marie Seymour, Benoit Lechat, Tomasz Jaworski, Peter Borghgraef, Herman Devijver, Geert Callewaert, Michael G. Stewart, and Fred Van Leuven, “Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy,” Plos One, vol. 9, no. 2, 2014.
- Maria del Carmen Cardenas-Aguayo, Laura Gomez-Virgilio, Steven DeRosa, and Marco Antonio Meraz-Rios, “The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology,” Acs Chemical Neuroscience, vol. 5, no. 12, pp. 1178–1191, 2014.
- Wolfgang Froestl, Andrea Pfeifer, and Andreas Muhs, “Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-Modifying Drugs. Update 2014,” Journal of Alzheimers Disease, vol. 42, no. 4, pp. 1079–1149, 2014.
- Sina Shadfar, Chul Ju Hwang, Mi-Sun Lim, Dong-Young Choi, and Jin Tae Hong, “Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents,” Archives of Pharmacal Research, 2015.
- Henrik H Hansen, Pernille Barkholt, Katrine Fabricius, Jacob Jelsing, Dick Terwel, Charles Pyke, Lotte Bjerre Knudsen, and Niels Vrang, “The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy,” Brain Research, 2015.
- Adrian G. Sandoval-Hernandez, Luna Buitrago, Herman Moreno, Gloria Patricia Cardona-Gomez, and Gonzalo Arboleda, “Role of Liver X Receptor in AD Pathophysiology,” Plos One, vol. 10, no. 12, 2015.
- PradipKumar Kamat, and Chandishwar Nath, “Okadaic acid: a tool to study regulatory mechanisms for neurodegeneration and regeneration in Alzheimer′s disease,” Neural Regeneration Research, vol. 10, no. 3, pp. 365, 2015.
- Vidya S. Krishnan, Zoe White, Chris D. McMahon, Stuart I. Hodgetts, Melinda Fitzgerald, Tea Shavlakadze, Alan R. Harvey, and Miranda D. Grounds, “A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice,” Journal of Neuropathology & Experimental Neurology, pp. nlw019, 2016.
- Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu, and Lu Shen, “The role of exosomes in the pathogenesis of Alzheimer’ disease,” Translational Neurodegeneration, vol. 6, no. 1, 2017.