Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

<table>(a) Marginal zone B cells in male and female rats dosed for 13 weeks with RO4929097. Spleen cell suspensions were analyzed by flow cytometry (FACS) using fluorescently labeled antibodies. For each rat the percentage of MZ B cells (= IgM<sup>high</sup>/CD90<sup>low/neg</sup>/HIS57<sup>+</sup>) in the leukocyte gate is shown. Dots represent individual rats. <b>-</b> = average per group. * = statistically significant difference to vehicle control (<svg height="11.375" id="M15" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). <svg height="11.125" id="M16" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 44.400002 11.125" width="44.400002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><path d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2
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</svg> rats/sex/group. (b) Splenic MZ B cells in male and female rats dosed for 13 weeks with RO4929097 followed by a recovery phase of 6 weeks. Dots represent individual rats. <b>- </b>= average per group. <svg height="11.225" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> rats/sex/group.</table>

International Journal of Alzheimer’s Disease

fig1

Figure 1

Figure 1: Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells 