𝛾-Secretase Modulators: Can We Combine Potency with Safety?

Figure 5

Evolution of our non-acid GSM series in relation to lipophilic efficiency parameters LELP and LLE. (a) LELP and LLE were calculated as described in Section 2. The highlighted section (LELP < 10, LLE > 5) indicates the desired area for drug-like compounds [35]. Each square indicates a compound, with the colour being indicative for when the compound has been synthesized during the project.