Vaccine Development to Treat Alzheimer’s Disease Neuropathology in APP/PS1 Transgenic Mice

Figure 5

Effect of EB101 vaccine on astrocytosis and activation of B and T cells in the brains of B6C3F1/J mice. Comparative photomicrographs of GFAP, CD45RA, and CD3 immunoreactivity in the hippocampus ((a)–(i), (l), (o), (r)) and cortical ((j), (k), (m), (n), (p), (q)) brain regions in the preventive treatment group ((a)–(i)) and therapeutic treatment group ((j)–(r)).

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