Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Figure 6

Compound 35 in the ATP binding pocket of GSK-3β; important protein-inhibitor interactions are shown. The distance is denoted by Å. PDB code 3M1S [62].

(a) Compound 35 in the ATP binding pocket of GSK-3β

(b) Rotated (a) to reveal the hydrophobic pocket containing Ile62, Phe67, Gly83, Val70, Lys85, and Glu97