Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Table 13

Examples of 1,2,4-oxadiazole inhibitors with biological activity against GSK-3, selectivity, X-ray, and reference.

No.	R^1	R^2	IC50 (nM)	Kinase panel	In vivo	X-ray	Year/lit.
123			β: 350	β + 8	Yes	—	2008 [129]
124			β: 410	β + 8	Yes	—	2008 [129]
125			β: 690	β + 8	Yes	—	2008 [129]
126			β: 710	—	Yes	—	2008 [129]
127			β: 1130	—	Yes	—	2008 [129]

β: GSK-3β.