Review Article

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Table 14

Examples of thiazole inhibitors with biological activity against GSK-3, selectivity, X-ray, and reference.

381029.table.0014a

No.R1IC50 (nM)Kinase panelIn vivoX-rayYear/lit.

128381029.table.0014bα/β: 130α/β + 21J1Bb2008 [130]
129381029.table.0014cα/β: 560α/β + 22008 [130]

381029.table.0014e

No.R2R3IC50/ (nM)Kinase PanelIn VivoX-rayYear/Lit.

130381029.table.0014dNO2β: 104b (38c)β + 26Yes1Q5K2003, 2005, 2007 [34, 131, 132]

aDocking studies, PDB code; bIC50 value; c value; α/β: GSK-3α/β; β: GSK-3β.