Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

Figure 5

Effect of GKW on survival of MC65 cells following tetracycline withdrawal. Cell viability is expressed as a % of the cell growth obtained in control cultures containing tetracycline, TET(+). On withdrawal of tetracycline from the media, TET(−), the cells generate endogenous Aβ and die within 3 days. In the absence of GKW, cell survival in TET(−) cultures is zero. GKW dose-dependently protects MC65 cells from cell death in TET(−) cultures (𝐏<𝟎.𝟎𝟏 at 50, 100, and 200 μg/mL compared to 0 μg/mL GKW; Student's t-test). Mean values of cell viability ± SD are shown.