Table 1: Baseline sample characteristics of patients with MCI with three years of followup.

VariablesAlzheimer’s Disease Neuroimaging Initiative (ADNI)Questionable Dementia (QD) study

Total %Nonconverter %Converter %Group difference Chi-square
value
Total ( )
%
Not converted ( )
%
Converted to AD ( ) %Group difference Chi-square value

Gender (% Male)67.0276.059.870.006326.1948.3939.390.3154
Race (%)
Caucasian92.2092.0092.360.891375.4077.4269.700.8452
Hispanic2.842.403.1816.6715.0521.21
African
 American
2.482.402.555.565.386.06
Other2.483.201.912.402.153.03
ApoE ε456.0340.0068.35<0.000127.2725.2733.330.5332

Mean (SD)Mean (SD)Mean (SD) -testMean (SD)Mean (SD)Mean (SD) -test

Age (years)74.59 (7.30)74.63 (7.66)74.56 (7.03)0.935167.31 (9.72)65.24 (9.69)73.12 (7.21)<0.0001
Education (years)15.76 (2.88)15.95 (2.81)15.60 (2.94)0.307415.18 (4.03)15.58 (3.77)14.06 (4.58)0.0507
MMSE27.08 (1.80)27.62 (1.74)26.66 (1.73)<0.000127.52 (2.21)28.02 (1.99)26.12 (2.20)<0.0001
AVLT/SRT34.14 (10.90)39.73 (12.16)29.69 (7.16)<0.000142.66 (9.49)45.60 (8.26)34.09 (7.50)<0.0001
FAQ2.84 (2.79)1.61 (2.08)3.82 (2.90)<0.00011.69 (2.05)1.28 (1.84)2.73 (2.21)0.0002

-test -test

Hippocampal volume6.30 (1.10)6.78 (1.01)5.92 (1.02)<0.00014.20 (0.73)4.37 (0.62)3.69 (0.74)<0.0001
Entorhinal cortex volume0.33 (0.08)0.36 (0.07)0.30 (0.07)<0.00010.45 (0.10)0.47 (0.09)0.38 (0.09)<0.0001
Intracranial volume1580.79 (166.15)1602.50 (152.48)1563.69 (174.67)0.05491306.60 (126.83)1317.43 (128.55)1273.71 (117.49)0.0919

MMSE: Mini-Mental State Exam, AVLT: Auditory Verbal Learning Test (sum of 6 trials), SRT: Selective Reminding Task (sum of 6 trials), FAQ: Pfeffer’s Functional Activities Questionnaire (10 items), SD: standard deviation, AD: Alzheimer’s disease. Hippocampal, entorhinal, and intracranial volumes are in cubic centimeters. Entorhinal cortex volumes measured in cubic millimeters in ADNI were converted to cubic centimeters. Intracranial volume in ADNI covered all intracranial structures including the cerebellum, but intracranial volume in QD was restricted to supratentorial intracranial volume.