A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease

Table 1

Summary of some transgenic mouse studies that have modulated inflammation and the effects these modulations had on the pathology.

Mode of inflammatory modulation	Genetic model of AD	Pathological changes observed				References
		Amyloid load	Tau pathology	Neuronal degeneration	Microglial “activation”
LPS intracranial	APP/PS1 amyloid	↓			↑	[5, 7]
LPS intracranial	rTg4510 tau		↑		↑	[8]
Anti-Aβ immunotherapy	APP amyloid	↓			↑	[13, 14]
Anti-Aβ immunotherapy	APP/NOS^−/− amyloid, tau, neuron loss	↓	↓	↓	↑	[17]
IL-1β overexpression in brain	APP/PS1 amyloid	↓			↑	[22]
TGFβ overexpression in brain	APP amyloid	↓			↑	[19]
TNFR1 and R2 deletion	3Xtg amyloid and tau	↑			↓	[21]