Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation through Classification of Alzheimer's Disease Patients

Table 1

Best discriminant models.

Model	Classification %	Cross-validation %	Regions used	Permutation significance
MMSE only	77.3	77.3	N/A	N/A
Unwarped PET data only	82.6	73.9	2,4,5,8,9	𝑃=3.42∗10^−3
Warped PET data only	87	73.9	4,5,8,9	𝑃=1.3∗10^−4
Unwarped PET data and MMSE	91.3	87	4,5,8,9	𝑃=8.6∗10^−4
Warped PET data and MMSE	100	95.7	4,5,8	𝑃<10^†−5

^†(None of the 100,000 permutations resulted in a model that performed as well as the true data).