Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics

Figure 2

APOE-related therapeutic response to a multifactorial therapy in patients with dementia. Cognitive performance (MMSE Score). Tb: basal MMSE score prior to treatment; Tt: MMSE score after 3 months of treatment in the total sample. E2/3b: basal MMSE score in APOE-2/3 carriers; E2/3t: MMSE score after treatment in APOE-2/3 carriers; E2/4b: Basal MMSE score in APOE-2/4 carriers; E2/4t: MMSE score after treatment in APOE-2/4 carriers; E3/3b: basal MMSE score in APOE-3/3 carriers; E3/3t: MMSE score after treatment in APOE-3/3 carriers; E3/4b: basal MMSE score in APOE-3/4 carriers; E3/4t: MMSE score after treatment in APOE-3/4 carriers; E4/4b: basal MMSE score in APOE-4/4 carriers; E4/4: MMSE score after treatment in APOE-4/4 carriers.