Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics

Figure 7

Distribution and frequency of CYP2D6 extensive metabolizers (EMs), intermediate metabolizers (IMs), poor metabolizers (PMs), and ultrarapid metabolizers (UMs) in patients with different CNS disorders. C: controls; ANX: anxiety; DEP: depression; PSY: psychotic disorders; STR: stroke; AD: Alzheimer’s disease; PAR: Parkinson’s disease; ADHD: attention-deficit hyperactivity disorder; MIG: migraine; EPI: epilepsy; VD: vascular dementia; VE: vascular encephalopathy; MS: multiple sclerosis; CVI: cerebrovascular insufficiency; BT: brain tumors; CNN: cranial nerve neuropathies; MR: mental retardation; PTBS: posttraumatic brain injury syndrome. Source: R. Cacabelos. CIBE Database. EuroEspes Biomedical Research Center, Institute for CNS Disorders, Coruña, Spain.