Research Article
Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps
Table 2
Equations for prediction of time to events and disease progression.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SD: standard deviation; AD: Alzheimer’s disease; VaD: vascular dementia; LBD: Lewy body dementia; LTD: frontotemporal dementia; CKD: chronic kidney disease; CVD: cerebrovascular disease; MMSE: mini-mental state examination; NPI: neuropsychiatric inventory; ADL: activities of daily living; IADL: instrumental activities of daily living, CG: caregiver. aPM represents patients’ previous MMSE measurement, partitioned over the scale of MMSE. PrevRate is the patients’ last known rate of decline. Age represents patients’ age at baseline. represents a random intercept parameter. bTreatment is dementia medication, Weeks represents weeks of followup in the simulation, NPIbase is the patient’s baseline NPI, and NPIrecent is the patient’s last NPI. White and Black are dummy variables for race, PsyMed is a dummy variable for patients on psychiatric medications at baseline, MMSEbase represents the patient’s MMSE at baseline, and MMSErecent represents the patient’s current MMSE. |