𝜸-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid 𝜷-Protein Production

Figure 1

βCTF is cleaved at the membrane-cytoplasm boundary and not in the middle of the transmembrane domain (ε-cleavage), to release the AICD49–99 and AICD50–99 species. The production of AICD species was inhibited in the presence of a γ-secretase inhibitor. ε-Cleavage is analogous to the S3 cleavage of mNotch-1. Red indicates the transmembrane domain.