-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid -Protein Production
Figure 2
Relationship between γ- and ε-cleavage. (a) Cells expressing wild-type PS or APP predominantly produce Aβ40 and AICD50–99, while cells expressing a FAD mutant of PS or APP exhibited increased proportion of Aβ42 and AICD49–99. (b) Expression of Aβ49 results in an increase in Aβ40/Aβ42 ratio, whereas expression of Aβ48 leads to opposite results. increase, decrease.
