𝜸-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid 𝜷-Protein Production

Figure 3

Tri- and tetrapeptide release from βCTF. (a) Upon ε-cleavage at ε48, γ-secretase releases the VIT and TVI tripeptides successively to produce Aβ42. (b) In the Aβ40 product line, after ε-cleavage at ε49, βCTF is converted into Aβ40 by releasing ITL, VIV, and IAT. Aβ42 is a direct substrate during Aβ38 production, which acts by releasing the VVIA tetrapeptide.

(a)

(b)