Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD
Table 4
Diagnostic features of the direct and calculated markers of the βAPB.
Marker
Cutoff (pg/mL)
Sensitivity (>85%)
Specificity (>80%)
ROC (>0.80)
UP Aβ1-40
23.2 AD
AD/HC
40.0
93.8
0.59
17.0 MCI
MCI/HC
85.7
68.8
0.80
22.5 AD
AD/MCI
40.0
71.4
0.35
DP Aβ1-40
63.8 AD
AD/HC
46.7
81.3
0.59
63.8 MCI
MCI/HC
85.7
81.3
0.81
72.2 AD
AD/MCI
40.0
71.4
0.36
CB Aβ1-40
71.9 AD
AD/HC
53.3
87.5
0.65
71.1 MCI
MCI/HC
85.7
81.3
0.85
211.3 AD
AD/MCI
13.3
100.0
0.40
UP Aβ1-42
10.28 AD
AD/HC
46.7
87.5
0.65
9.2 MCI
MCI/HC
85.7
81.3
0.90
67.4 AD
AD/MCI
6.7
100.0
0.26
DP Aβ1-42
47.4 AD
AD/HC
46.7
87.5
0.62
50.3 MCI
MCI/HC
57.1
93.8
0.79
151.7 AD
AD/MCI
6.7
100.0
0.35
CB Aβ1-42
76.9 AD
AD/HC
40.0
100.0
0.74
59.8 MCI
MCI/HC
100.0
50.0
0.72
71.3 AD
AD/MCI
53.3
71.4
0.48
T40 (DP + CB)
132.7 AD
AD/HC
53.3
81.3
0.60
132.7 MCI
MCI/HC
85.7
81.3
0.83
550.8 AD
AD/MCI
13.3
100
0.37
T42 (DP + CB)
115.8 AD
AD/HC
53.3
87.5
0.71
103.3 MCI
MCI/HC
100
50
0.77
113.7 AD
AD/MCI
53.3
57.1
0.41
T-βAPB (T40 + T42)
235.5 AD
AD/HC
53.3
81.3
0.65
235.5 MCI
MCI/HC
85.7
81.3
0.84
778.1 AD
AD/MCI
13.3
100
0.38
Highlighted in bold are the results that met the criterion considered suitable as figure in the heading. PPV: positive predictive value. NPV: negative predictive value. ROC: area under the receiver operating characteristic curve.
