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International Journal of Alzheimer’s Disease
Volume 2012, Article ID 608732, 5 pages
http://dx.doi.org/10.1155/2012/608732
Review Article

Traumatic Brain Injury, Microglia, and Beta Amyloid

1Division of Emergency Medicine, Department of Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02124, USA
2Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
3Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA

Received 30 November 2011; Accepted 2 March 2012

Academic Editor: Joseph El Khoury

Copyright © 2012 Rebekah C. Mannix and Michael J. Whalen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recently, there has been growing interest in the association between traumatic brain injury (TBI) and Alzheimer’s Disease (AD). TBI and AD share many pathologic features including chronic inflammation and the accumulation of beta amyloid (Aβ). Data from both AD and TBI studies suggest that microglia play a central role in Aβ accumulation after TBI. This paper focuses on the current research on the role of microglia response to Aβ after TBI.