Microglial Amyloid-1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease
Figure 6
Laser confocal microscopic study on the accumulation of HMGB1 and microglia on A40 plaques in human AD brains. (a–c) Free-floating human AD brain sections were incubated with the anti-A40 specific antibody ((a) red) and anti-HLA-DR antibody ((b) for microglial staining, green). The merged image is indicated in (c). (d–f) Free-floating human AD brain sections were incubated with the anti-A40 specific antibody ((a); red) and anti-HMGB1 antibody ((b); green). The merged image is indicated in (f). Scale bar in (a) equals 50 μm for all panels.
