TY - JOUR A2 - Porsteinsson, Anton P. AU - Berk, Camryn AU - Sabbagh, Marwan PY - 2012 DA - 2011/12/01 TI - Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease SP - 707468 VL - 2012 AB - Donepezil, a highly selective acetylcholinesterase inhibitor (AChEI), is approved as a symptomatic treatment mild, moderate, and severe Alzheimer's disease (AD). Donepezil exerts its treatment effect through multiple mechanisms of action including nicotinic receptor stimulation, mitigation of excitotoxicity, and influencing APP processing. The use of donepezil at higher doses is justified given the worsening cholinergic deficit as the disease advances. Donepezil has been investigated in several clinical trials of subjects with moderate-to-severe AD. While the side effects are class specific (cholinergically driven), demonstrable benefit has been shown at the 10 mg dose and the 23 mg doses. Here, we review the clinical justification, efficacy, safety, and tolerability of use of donepezil in the treatment of moderate-to-severe AD. SN - 2090-8024 UR - https://doi.org/10.1155/2012/707468 DO - 10.1155/2012/707468 JF - International Journal of Alzheimer’s Disease PB - Hindawi Publishing Corporation KW - ER -