Structure and Pathology of Tau Protein in Alzheimer Disease

Figure 1

Amino acid sequence of the longest tau isoform (441 amino acids). N1 and N2: the polypeptide sequences encoded by exons 2 and 3; P1 and P2: proline-rich regions; R1–R4: microtubule-binding domains encoded by exons 9–12; ²⁷⁵VQIINK²⁸⁰ and ³⁰⁶VQIVYK³¹¹: sequences with β-structure (modified by [13]).