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International Journal of Alzheimer’s Disease
Volume 2012 (2012), Article ID 974013, 8 pages
http://dx.doi.org/10.1155/2012/974013
Research Article

Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress

Centre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, India

Received 29 October 2011; Revised 24 December 2011; Accepted 9 January 2012

Academic Editor: Francesco Panza

Copyright © 2012 Puchchakayala Goverdhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. D. Jewart and J. Green, “Cognitive, behavioral, and physiological changes in Alzheimer's disease patients as a function of incontinence medications,” American Journal of Geriatric Psychiatry, vol. 13, no. 4, pp. 324–328, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. D. J. Selkoe, “Alzheimer's disease: a central role for amyloid,” Journal of Neuropathology and Experimental Neurology, vol. 53, no. 5, pp. 438–447, 1994. View at Google Scholar · View at Scopus
  3. R. Becker, E. Giacobini, R. Elble, M. McIlhany, and K. Sherman, “Potential pharmacotherapy of Alzheimer disease. A comparison of various forms of physostigmine administration,” Acta Neurologica Scandinavica, vol. 77, supplement 116, pp. 19–32, 1988. View at Google Scholar · View at Scopus
  4. K. Rockwood, “Biomarkers to measure treatment effects in Alzheimer's disease: What should we look for?” International Journal of Alzheimer's Disease, vol. 2011, Article ID 598175, 4 pages, 2011. View at Publisher · View at Google Scholar
  5. G. M. Bores, F. P. Huger, W. Petko et al., “Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine,” Journal of Pharmacology and Experimental Therapeutics, vol. 277, no. 2, pp. 728–738, 1996. View at Google Scholar · View at Scopus
  6. I. Silman and J. L. Sussman, “Acetylcholinesterase: “classical” and “non-classical” functions and pharmacology,” Current Opinion in Pharmacology, vol. 5, no. 3, pp. 293–302, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. J. H. Oh, B. J. Choi, M. S. Chang, and S. K. Park, “Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression,” Neuroscience Letters, vol. 461, no. 1, pp. 41–44, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Fan, J. Hu, J. Li et al., “Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms,” Neuroscience Letters, vol. 374, no. 3, pp. 222–226, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Chen, Y. Long, M. Han, T. Wang, Q. Chen, and R. Wang, “Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice,” Pharmacology Biochemistry and Behavior, vol. 90, no. 3, pp. 441–446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. P. P. Zandi, J. C. Anthony, A. S. Khachaturian et al., “Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the cache county study,” Archives of Neurology, vol. 61, no. 1, pp. 82–88, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Sano, C. Ernesto, R. G. Thomas et al., “A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease,” The New England Journal of Medicine, vol. 336, no. 17, pp. 1216–1222, 1997. View at Publisher · View at Google Scholar
  12. T. Wyss-Coray and L. Mucke, “Inflammation in neurodegenerative disease—a double-edged sword,” Neuron, vol. 35, no. 3, pp. 419–432, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. W. L. Smith, D. L. DeWitt, and R. M. Garavito, “Cyclooxygenases: structural, cellular, and molecular biology,” Annual Review of Biochemistry, vol. 69, pp. 145–182, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Nivsarkar, “Improvement in circulating superoxide dismutase levels: role of nonsteroidal anti-inflammatory drugs in rheumatoid arthritis,” Biochemical and Biophysical Research Communications, vol. 270, no. 3, pp. 714–716, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Kimura, “Mechanisms of active oxygen species reduction by non-steroidal anti-inflammatory drugs,” International Journal of Biochemistry and Cell Biology, vol. 29, no. 3, pp. 437–446, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. C. M. Y. Burak, O. B. Cimen, G. Eskandari, G. Sahin, C. Erdogon, and U. Atik, “In vivo effects of meloxicam, celecoxib and ibuprofen on free radical mechanism in human erythrocytes,” Drug and Chemical Toxicology, vol. 26, no. 3, pp. 169–176, 2003. View at Publisher · View at Google Scholar
  17. J. Knoll, “The pharmacology of selegiline ((−)deprenyl). New aspects,” Acta Neurologica Scandinavica, Supplement, vol. 126, pp. 83–91, 1989. View at Publisher · View at Google Scholar · View at Scopus
  18. P. D. Kulkarni, M. M. Ghaisas, N. D. Chivate, and P. S. Sankpal, “Memory enhancing activity of Cissampelos pareira in mice,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, no. 2, pp. 206–211, 2011. View at Google Scholar
  19. S. Indumathy, S. Kavimani, and K. V. Raman, “Role of angiotensin antagonists in memory enhancement,” International Journal of Pharma and Bio Sciences, vol. 1, no. 3, 2010. View at Google Scholar
  20. H. G. Vogel, B. A. Schlkens, J. Sandow et al., “Drug effects on learning and memory,” in Drug Discovery and Evaluation: Pharmacological Assays, pp. 595–643, Springer, Berlin, Germany, 2nd edition, 2002. View at Google Scholar
  21. R. Morris, “Developments of a water-maze procedure for studying spatial learning in the rat,” Journal of Neuroscience Methods, vol. 11, no. 1, pp. 47–60, 1984. View at Publisher · View at Google Scholar · View at Scopus
  22. M. K. Saraf, S. Prabhakar, K. L. Khanduja, and A. Anand, “Bacopa monniera attenuates scopolamine-induced impairment of spatial memory in mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 236186, 10 pages, 2011. View at Publisher · View at Google Scholar
  23. Z. F. Yu, G. J. Cheng, and B. R. Hu, “Mechanism of colchicine impairment of learning and memory, and protective effect of CGP36742 in mice,” Brain Research, vol. 750, no. 1-2, pp. 53–58, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Abhinav, M. Jogender, K. Madhusudana, V. G. M. Naidu, and Y. K. Gupta, “Anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats,” Pharmacology & Pharmacy, vol. 1, no. 1, pp. 1–8, 2010. View at Publisher · View at Google Scholar
  25. A. Kumar, D. Samrita, and A. Prakash, “Neuroprotective effects of Centella asiatica against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress,” International Journal of Alzheimer's Disease, vol. 2009, Article ID 972178, 8 pages, 2009. View at Publisher · View at Google Scholar
  26. I. P. Kaur and T. Geetha, “Screening methods for antioxidants—a review,” Mini-Reviews in Medicinal Chemistry, vol. 6, no. 3, pp. 305–312, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Luck and H. U. Bergmeyer, Catalase in Methods of Enzymatic Analysis, Academic Press, NewYork, NY, USA, 1971.
  28. W. F. Stewart, C. Kawas, M. Corrada, and E. J. Metter, “Risk of Alzheimer's disease and duration of NSAID use,” Neurology, vol. 48, no. 3, pp. 626–632, 1997. View at Google Scholar · View at Scopus
  29. B. A. In 't Veld, A. Ruitenberg, A. Hofman et al., “Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease,” The New England Journal of Medicine, vol. 345, no. 21, pp. 1515–1521, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. D. A. El-Sherbiny, A. E. Khalifa, A. S. Attia, and E. E. S. Eldenshary, “Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine,” Pharmacology Biochemistry and Behavior, vol. 76, no. 3-4, pp. 525–533, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. E. J. Jeong, K. Y. Lee, S. H. Kim, S. H. Sung, and Y. C. Kim, “Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice,” European Journal of Pharmacology, vol. 588, no. 1, pp. 78–84, 2008. View at Publisher · View at Google Scholar · View at Scopus