Research Article

Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer’s Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation

Figure 2

Inflammatory proteins induce tau hyperphosphorylation in AD-associated regions in the brain: PHF-1 and p-Ser202 Tau phosphorylation in different brain regions—hippocampus (a), cerebral cortex (b), and striatum (c) from control mice (mTau), and mouse expressing ACT/mTau and ACT/mTau/hTau transgenes injected with CSF and IL-1β (1 ng/10 μL) * , ** (calculated from aCSF versus IL-1β treated group). Values were normalized to actin levels. The blot above each bar graph shows a representative western blot showing corresponding P-tau in the samples from different mice. The data was collected from four independent mice from each genotype group.
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