Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction

<table>Cu content in human brain. Illustrates a significant decrease in total Cu in the soluble fraction of the extracted brain tissue. *<svg height="11.375" id="M31" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>; one-way ANOVA with Bonferroni’s multiple comparison post hoc test of log transformed data. Cu is decreased in AD frontal cortex. Copper is significantly decreased in the total homogenate and soluble extracted material (<svg height="11.375" id="M33" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). The only fraction that had a significant decrease was the soluble fraction indicating that the decrease in Cu observed in the total homogenate is localized to changes in the soluble fraction. HC <i>Healthy Control </i>(clear boxes), AD <i>Alzheimer’s disease </i>(filled boxes).</table>

International Journal of Alzheimer’s Disease

fig1

Figure 1

Figure 1: Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction 