Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration

Table 2

Ratio Aβ(1–42)/(1–40) in plasma and brain cortex and hippocampus after the experimental diets.

Diets	Plasma	Brain
		Cortex	Hippocampus
C	6.5 ± 1.0^a	7.3 ± 0.9^a	6.3 ± 0.7^a
Cu	6.8 ± 0.8^a	9.2 ± 0.5^b	6.6 ± 0.4^a
Cho	7.1 ± 1.1^a	9.2 ± 0.6^b	9.6 ± 0.5^b
CuCho	8.5 ± 0.8^a	10.9 ± 0.5^c	9.3 ± 0.6^b

Data were obtained as described in Section 2.12. They correspond to the mean of 10 individual determinations assayed in triplicate ± SD. Differences statistically significant among the different diets are indicated with distinct superscript letters.