In Vivo Characterization of a Novel 𝜸-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Table 3

Concentration of SCH 697466 (𝜇M) in plasma and brain for various sub-chronic studies in TgCRND8 and non-transgenic mice.

Dose (mg/kg)	TgCRND8 mouse		Nontransgenic mouse
	6 days b.i.d.		11 days q.d.		6 days b.i.d.
	Plasma	Brain	Plasma	Brain	Plasma	Brain
3	0.02 ± 0.003	0.003 ± 0.003	0.03 ± 0.01	BLOQ	0.06 ± 0.04	BLOQ
10	0.47 ± 0.06	0.05 ± 0.01	0.43 ± 0.06	0.01 ± 0.0002	0.35 ± 0.05	BLOQ
30	2.64 ± 0.29	0.32 ± 0.05	2.99 ± 0.22	0.20 ± 0.03	2.03 ± 0.56	0.10 ± 0.02
100	ns	14.96 ± 5.44	8.10 ± 0.84	2.63 ± 0.52	10.21 ± 0.68	3.15 ± 0.54

ns: No samples; BLOQ: below the limit of quantification (0.003 𝜇M).