The Beta-Amyloid Protein of Alzheimer’s Disease: Communication Breakdown by Modifying the Neuronal Cytoskeleton

<table>The processing of APP through the beta-site A<i>β</i>PP-cleaving enzyme BACE1, followed by presenilin-1 (PS1). Sequential beta and gamma-secretase cleavage of APP generates the synaptotoxic amyloid-<i>β</i> (A<i>β</i>) peptide species, A<i>β</i>1-40 and A<i>β</i>1-42.</table>

International Journal of Alzheimer’s Disease

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Figure 1

Figure 1: The Beta-Amyloid Protein of Alzheimer’s Disease: Communication Breakdown by Modifying the Neuronal Cytoskeleton 