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International Journal of Alzheimer’s Disease
Volume 2014 (2014), Article ID 150628, 6 pages
Research Article

The Association between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment among Different Ethnic Minority Groups in China

1Department of Epidemiology and Biostatistics, School of Public Health, Ningxia Medical University, Yinchuan 750004, China
2Department of Comprehensive Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, China
3Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia

Received 8 May 2014; Revised 2 July 2014; Accepted 16 July 2014; Published 5 August 2014

Academic Editor: Lucilla Parnetti

Copyright © 2014 ZhiZhong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The association, in different ethnic groups, of apolipoprotein E (apoE) gene polymorphism with mild cognitive impairment (MCI) has been unclear. Few studies have examined the association in Chinese minorities. The current study explores the association between apoE gene polymorphism and MCI in one of the biggest ethnic groups—the Hui—and compares it with the Han. The Minimental State Exam, Activities of Daily Living Scale, and Geriatric Depression Scale were administered to 306 ethnic Hui and 618 ethnic Han people aged 55 years. ApoE genotypes were determined using the high resolution melting curve method. The distribution of the apoE genotype and the frequency of alleles 2, 3, and 4 were similar in the Hui and Han groups. In analyses adjusted for age, gender, and education level, the 4 allele was a risk factor for MCI in both the Hui group ( .61, 95% CI: 1.02–6.66) and the Han group ( .36, 95% CI: 1.19–4.67), but the apoE 2 allele was protective for MCI only in the Han group ( .48, 95% CI: 0.38–0.88). The association of some apoE genotypes with MCI may differ in different ethnic groups in China. Further studies are needed to explore this effect among different populations.