High-Dimensional Medial Lobe Morphometry: An Automated MRI Biomarker for the New AD Diagnostic Criteria

Table 2

Discrimination of controls versus probable AD.

Data set	Data type	VOI	Correct Rate	Sn	Sp	Sn + Sp
Intensity standardisation testing
Study	Original intensity + determinant	MTL	0.741	0.705	0.776
Study	STI intensity + determinant	MTL	0.744	0.732	0.758
Study	GM + determinant	MTL	0.779	0.763	0.792
Volume of interest testing
Study	GM + determinant	MTL	0.779	0.763	0.792	1.652
Study	GM + determinant	Segmented	0.778	0.739	0.815
Study	GM + determinant	Brain	0.691	0.660	0.718
Large-scale testing
Study	GM + determinant	MTL	0.779	0.763	0.792
Comparison	GM + determinant	MTL	0.787	0.725	0.851

STI: intensity standardisation technique; GM: grey matter; VOI: volume of interest; MTL: medial temporal lobe volume; Sn: sensitivity; Sp: specificity.