High-Dimensional Medial Lobe Morphometry: An Automated MRI Biomarker for the New AD Diagnostic Criteria

Table 3

Discrimination controls versus MCI progressors.

Data set	Data type	VOI	Correct rate	Sn	Sp	Sn + Sp
Intensity standardisation testing
Study	Original intensity + Determinant	MTL	0.700	0.742	0.649
Study	STI intensity + determinant	MTL	0.721	0.780	0.623
Study	GM + determinant	MTL	0.722	0.792	0.634
Volume of interest testing
Study	GM + determinant	MTL	0.722	0.792	0.634
Study	GM + determinant	Segmented	0.708	0.730	0.681
Study	GM + determinant	Brain	0.683	0.785	0.550
Large-scale testing
Study	GM + determinant	MTL	0.722	0.792	0.634
Comparison	GM + determinant	MTL	0.594	0.824	0.478