High-Dimensional Medial Lobe Morphometry: An Automated MRI Biomarker for the New AD Diagnostic Criteria

Table 4

Discrimination of MCI progressors versus nonprogressors.

Data set	Data type	VOI	Correct rate	Sn	Sp	Sn + Sp
Intensity standardisation testing
Study	Original intensity + determinant	MTL	0.606	0.278	0.843
Study	STI intensity + Determinant	MTL	0.635	0.372	0.824
Study	GM + determinant	MTL	0.622	0.346	0.820
Volume of interest testing
Study	GM + determinant	MTL	0.622	0.346	0.820
Study	GM + determinant	Segmented	0.612	0.340	0.794
Study	GM + determinant	Brain	0.572	0.145	0.878
Large-scale testing
Study	GM + determinant	MTL	0.622	0.346	0.820
Comparison	GM + determinant	MTL	0.660	0.029	1.000	1.029