Neprilysin Is Poorly Expressed in the Prefrontal Cortex of Aged Dogs with Cognitive Dysfunction Syndrome

Table 1

Characteristics and NEP expression values of the animals.

Dogs	Breed	Sex	Cause of death	Age (years)	NEP expression (ru)
Young (2–4 years)
1	Mongrel	F	Babesiosis	4.0	0.706
2	Beagle	M	Hunting injuries	4.0	4.705
3	Epagneul Breton	M	Hunting injuries	2.0	0.669
4	Ibizan Hound	M	Urethral rupture	3.0	1.308
5	Mongrel	M	Car accident	4.0	3.902
6	Mongrel	M	Rodenticide toxicosis	3.0	1.627
			Mean ± S.D.	3.3  ±  0.8	2.15  ±  1.72
Aged-CU (11–16 years)
7	Mongrel	M	Urolithiasis	16.0	0.961
8	Mongrel	F	Mammary tumors	14.0	2.298
9	Teckel	F	Intervertebral disk disease	13.0	3.888
10	Fox Terrier	M	Chronic kidney disease	12.0	3.864
11	Mongrel	M	Tracheal collapse, bronchitis	11.0	1.014
12	Toy poodle	M	Mitral valve disease	16.0	1.462
			Mean ± S.D.	13.7  ±  2.1	2.25  ±  1.35
Aged-CI (12–17 years)
13	Chiwawa	M	Severe cognitive damage	17.5	0.571
14	Mongrel	M	Severe cognitive damage	16.0	0.366
15	Cocker Spaniel	M	Severe cognitive damage	12.8	0.199
16	Toy poodle	F	Severe cognitive damage	14.0	0.671
17	Pekingese	M	Severe cognitive damage	16.0	0.696
18	West Highland	F	Severe cognitive damage	14.0	0.173
			Mean ± S.D.	15.05  ±  1.7	0.45  ±  0.23