PET Imaging of Epigenetic Influences on Alzheimer’s Disease

Figure 7

Representative sagittal PET images comparing the standard uptake value ratios (SUVRs) of [¹⁸F]florbetapir between cognitively normal (CN), amnestic mild cognitive impairment negative for cerebral Aβ, aMCI(−), amnestic mild cognitive impairment positive for cerebral Aβ, aMCI(+), and Alzheimer’s disease (AD) patients. Note that higher [¹⁸F]florbetapir accumulation was especially prominent in parietal, temporal, and occipital gyri. This study also concluded that there was a significant difference between scores on the Mini Mental State Examination for neurocognitive testing and [¹⁸F]florbetapir SUVRs amid CN, aMCI(−), aMCI(+), and AD subjects ([56], reprinted with permission).