Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia
Table 1
Baseline characteristics of patients with mild dementia stratified by Cornell Scores.
Variables
Total ()
Category
Cornell score 0–7 ()
Cornell score 8–10 ()
Cornell score >10 ()
Test ( value)
Age, median (interquartile range)
77.1 (9.4)
77.1 (9.1)
75.7 (9.8)
78.6 (12.4)
0.15
Sex
151
Male
112
21
18
0.41
179
Female
130
33
16
Household status
102
Living alone
78
14
10
0.65
228
Living with others
164
40
24
Education
205
Short education (<3 yrs)
151
34
20
0.10
90
Medium education (3-4 yrs)
70
14
6
35
Long education (>4 yrs)
21
6
8
Smoking status
95
Never smoked
70
15
10
0.99
147
Past smoker
108
25
14
88
Current smoker
64
14
10
Alcohol consumption
26
No alcohol
20
2
4
0.20
235
≤1 unit per day
171
39
25
57
2-3 units per day
45
8
4
12
>3 units per day
6
5
1
BMI
172
Normal
124
29
19
0.41
118
Overweight
88
21
9
39
Obese
30
3
6
MMSE, median (interquartile range)
24.0 (4.0)
24.0 (4.0)
24.0 (5.0)
24.0 (4.0)
0.76
Dementia format
239
Probable AD
175
43
21
0.12
82
Mixed AD
62
10
10
9
DLB
5
1
3
CCI
137
0
110
14
13
0.01
140
1
90
34
16
53
2
42
6
5
Anosognosia
35
No awareness
28
5
2
0.66
196
Shallow awareness
139
36
21
98
Full awareness
75
13
10
Treated with antidepressants within 12 months
85
Yes
55
15
15
0.02
239
No
183
38
18
QoL-AD, median (interquartile range)
33.0 (8.0)
35.0 (8.0)
30.0 (7.0)
29.0 (8.0)
<0.0001
ADSC-ADL, median (interquartile range)
64.0 (16.0)
65.0 (16.0)
62.5 (13.0)
61.0 (15.0)
0.04
NPIQ, median (interquartile range)
3.0 (4.0)
2.0 (3.0)
6.0 (6.0)
7.0 (7.0)
<0.0001
Randomisation
163
Control
110
32
21
0.06
167
DAISY intervention
132
22
13
MMSE = Mini-Mental State Examination. Probable AD = probable Alzheimer’s disease. Mixed AD = mixed Alzheimer’s disease with vascular component. DLB = dementia with Lewy bodies. QoL-AD = Quality of Life Scale for Alzheimer’s Disease. ADSC-ADL = Alzheimer’s Disease Cooperative Study Activities of Daily Living Scale. CCI = Charlson Comorbidity Index. values are from a Kruskal-Wallis test (continuous variables) or a Pearson chi-squared test (categorical variables).
