Table of Contents Author Guidelines Submit a Manuscript
International Journal of Alzheimer’s Disease
Volume 2017 (2017), Article ID 8584205, 7 pages
https://doi.org/10.1155/2017/8584205
Research Article

Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer’s Disease

Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan

Correspondence should be addressed to Yasushi Kishimoto; pj.ca.u-irnub.hpk@tomihsik

Received 29 August 2017; Revised 31 October 2017; Accepted 6 November 2017; Published 27 November 2017

Academic Editor: Jeff Kuret

Copyright © 2017 Yasushi Kishimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Crews and E. Masliah, “Molecular mechanisms of neurodegeneration in Alzheimer's disease,” Human Molecular Genetics, vol. 19, no. 1, pp. R12–R20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Hardy and D. Allsop, “Amyloid deposition as the central event in the aetiology of Alzheimer's disease,” Trends in Pharmacological Sciences, vol. 12, no. 10, pp. 383–388, 1991. View at Publisher · View at Google Scholar · View at Scopus
  3. G. A. Carlesimo and M. Oscar-Berman, “Memory deficits in Alzheimer's patients: a comprehensive review,” Neuropsychology Review, vol. 3, no. 2, pp. 119–169, 1992. View at Publisher · View at Google Scholar · View at Scopus
  4. C. A. Gold and A. E. Budson, “Memory loss in Alzheimer's disease: implications for development of therapeutics,” Expert Review of Neurotherapeutics, vol. 8, no. 12, pp. 1879–1891, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. K. G. White and A. C. Ruske, “Memory deficits in Alzheimer's disease: the encoding hypothesis and cholinergic function,” Psychonomic Bulletin & Review, vol. 9, no. 3, pp. 426–437, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Haass and D. J. Selkoe, “Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide,” Nature Reviews Molecular Cell Biology, vol. 8, no. 2, pp. 101–112, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Hardy and D. J. Selkoe, “The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics,” Science, vol. 297, no. 5580, pp. 353–356, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Walter, C. Kaether, H. Steiner, and C. Haass, “The cell biology of Alzheimer's disease: Uncovering the secrets of secretases,” Current Opinion in Neurobiology, vol. 11, no. 5, pp. 585–590, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Hardy, “The Alzheimer family of diseases: Many etiologies, one pathogenesis?” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 94, no. 6, pp. 2095–2097, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. D. L. Price and S. S. Sisodia, “Mutant genes in familial Alzheimer's disease and transgenic models,” Annual Review of Neuroscience, vol. 21, no. 1, pp. 479–505, 1998. View at Publisher · View at Google Scholar
  11. K. Hsiao, P. Chapman, S. Nilsen et al., “Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice,” Science, vol. 274, no. 5284, pp. 99–102, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. K. H. Ashe and K. R. Zahs, “Probing the Biology of Alzheimer's Disease in Mice,” Neuron, vol. 66, no. 5, pp. 631–645, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. S. G. Anagnostaras, G. D. Gale, and M. S. Fanselow, “Hippocampus and contextual fear conditioning: recent controversies and advances,” Hippocampus, vol. 11, no. 1, pp. 8–17, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. P. C. Holland and M. E. Bouton, “Hippocampus and context in classical conditioning,” Current Opinion in Neurobiology, vol. 9, no. 2, pp. 195–202, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. K. A. Corcoran, Y. Lu, R. Scott Turner, and S. Maren, “Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease,” Learning & Memory, vol. 9, no. 5, pp. 243–252, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. J. S. Jacobsen, C.-C. Wu, J. M. Redwine et al., “Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 103, no. 13, pp. 5161–5166, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. K. T. Dineley, X. Xia, D. Bui, J. David Sweatt, and H. Zheng, “Accelerated plaque accumulation, associative learning deficits, and up-regulation of α7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins,” The Journal of Biological Chemistry, vol. 277, no. 25, pp. 22768–22780, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Wang, K. T. Dineley, J. D. Sweatt, and H. Zheng, “Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis,” Neuroscience, vol. 126, no. 2, pp. 305–312, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Caccamo, S. Oddo, L. M. Billings et al., “M1 receptors play a central role in modulating AD-like pathology in transgenic mice,” Neuron, vol. 49, no. 5, pp. 671–682, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Clausen, X. Xu, X. Bi, and M. Baudry, “Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline,” Journal of Alzheimer's Disease, vol. 30, no. 1, pp. 183–208, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. J. G. Richards, G. A. Higgins, A.-M. Ouagazzal et al., “PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation,” The Journal of Neuroscience, vol. 23, no. 26, pp. 8989–9003, 2003. View at Google Scholar · View at Scopus
  22. T. Shimizu, T. Toda, Y. Noda, G. Ito, and M. Maeda, “Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 617974, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Kishimoto and Y. Kirino, “Presenilin 2 mutation accelerates the onset of impairment in trace eyeblink conditioning in a mouse model of Alzheimer's disease overexpressing human mutant amyloid precursor protein,” Neuroscience Letters, vol. 538, pp. 15–19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Chen, A. D. Steele, S. Lindquist, and L. Guarente, “Medicine: Increase in activity during calorie restriction requires Sirt1,” Science, vol. 310, no. 5754, p. 1641, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. V. Roughan, S. L. Wright-Williams, and P. A. Flecknell, “Automated analysis of postoperative behaviour: Assessment of homecagescan as a novel method to rapidly identify pain and analgesic effects in mice,” Laboratory Animals, vol. 43, no. 1, pp. 17–26, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Hiasa, Y. Isoda, Y. Kishimoto et al., “Inhibition of MAO-A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir,” British Journal of Pharmacology, vol. 169, no. 1, pp. 115–129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Kishimoto, B. Cagniard, M. Yamazaki et al., “Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol,” Frontiers in Behavioral Neuroscience, vol. 9, no. JUNE, article no. A134, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Kishimoto, E. Higashihara, A. Fukuta, A. Nagao, and Y. Kirino, “Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease,” Brain Research, vol. 1491, pp. 117–126, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. T. A. Comery, R. L. Martone, S. Aschmies et al., “Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease,” The Journal of Neuroscience, vol. 25, no. 39, pp. 8898–8902, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Raber, L. Villasana, J. Rosenberg, Y. Zou, T. T. Huang, and J. R. Fike, “Irradiation enhances hippocampus-dependent cognition in mice deficient in extracellular superoxide dismutase,” Hippocampus, vol. 21, no. 1, pp. 72–80, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. S. A. Villeda, J. Luo, K. I. Mosher et al., “The ageing systemic milieu negatively regulates neurogenesis and cognitive function,” Nature, vol. 477, pp. 90–94, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Barnes and M. Good, “Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene,” Behavioural Brain Research, vol. 157, no. 1, pp. 107–117, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. P. L. Pugh, J. C. Richardson, S. T. Bate, N. Upton, and D. Sunter, “Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease,” Behavioural Brain Research, vol. 178, no. 1, pp. 18–28, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. D. L. Algase, “Wandering in dementia,” Annual Review of Nursing Research, vol. 17, pp. 185–217, 1999. View at Google Scholar · View at Scopus
  35. A. Goate, M.-C. Chartier-Harlin, M. Mullan et al., “Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease,” Nature, vol. 349, no. 6311, pp. 704–706, 1991. View at Publisher · View at Google Scholar · View at Scopus
  36. D. L. Price, R. E. Tanzi, D. R. Borchelt, and S. S. Sisodia, “Alzheimer's disease: Genetic studies and transgenic models,” Annual Review of Genetics, vol. 32, pp. 461–493, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Tomita, K. Maruyama, T. C. Saido et al., “The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 94, no. 5, pp. 2025–2030, 1997. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Ohno, L. Chang, W. Tseng et al., “Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1,” European Journal of Neuroscience, vol. 23, no. 1, pp. 251–260, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. M. L. Woolley and T. M. Ballard, “Age-related impairments in operant DMTP performance in the PS2APP mouse, a transgenic mouse model of Alzheimer's disease,” Behavioural Brain Research, vol. 161, no. 2, pp. 220–228, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Poling, K. Morgan-Paisley, J. J. Panos et al., “Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures,” Behavioural Brain Research, vol. 193, no. 2, pp. 230–234, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. M. A. Westerman, D. Cooper-Blacketer, A. Mariash et al., “The relationship between Aß and memory in the Tg2576 mouse model of Alzheimer’s disease,” The Journal of Neuroscience, vol. 22, no. 5, pp. 1858–1867, 2002. View at Google Scholar · View at Scopus
  42. K. Duff, C. Eckman, C. Zehr et al., “Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1,” Nature, vol. 383, no. 6602, pp. 710–713, 1996. View at Publisher · View at Google Scholar · View at Scopus
  43. M. N. Gordon, D. L. King, D. M. Diamond et al., “Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice,” Neurobiology of Aging, vol. 22, no. 3, pp. 377–385, 2001. View at Publisher · View at Google Scholar · View at Scopus