Research Article
Amyloid-Beta 1-42 Cross-Reactive Antibody Prevalent in Human Sera May Contribute to Intraneuronal Deposition of A-Beta-P-42
Table 1
Comparison of immunoreactivity of anti-AβP-42 antibody with different neuronal or associated antigens using reactivity with AßP-42 peptide as 100%.
| | Variables | Percentage of reactivity | Strength of reactivity w/ monoclonal AP-42 |
| | AßP-42 peptide | 100% | Very highly positive | | Amyloid β protein | 97% | Very highly positive | | Tau protein | 58% | Highly positive | | α-synuclein | 32% | Moderately positive | | Presenilin | 95% | Very highly positive | | Adenosine triphosphate synthase | 7% | Non-reactive | | Rabaptin-5 | 74% | Highly positive | | S100B | 22% | Low positive | | Aquaporin-4 | 37% | Moderately positive | | Claudin-5 | 5% | Non-reactive | | Glial fibrillary acidic protein | 29% | Low positive | | Myelin basic protein | 20% | Low positive | | Asialoganglioside GM1 | 5% | Non-reactive | | β-nerve growth factor | 74% | Highly positive | | Brain-derived neurotrophic factor | 55% | Highly positive | | Glutamate receptor | 10% | Equivocal | | N-methyl-D-aspartate receptor | 6% | Nonreactive | | Dopamine receptors 1, 2 | 5% | Nonreactive | | Glutamic acid decarboxylase 65 | 7% | Nonreactive | | Transglutaminase-2 | 18% | Low positive | | Transglutaminase-3 | 25% | Low positive | | Microbial transglutaminase | 55% | Highly positive | | Enteric nerve neuronal nuclear antigen | 87% | Very highly positive |
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0-0.27 OD: nonreactive, 0.271-0.50: equivocal, 0.51-1.2: low positive, 1.21-2.0: moderately positive, 2.01-3.0: highly positive, and >3.0: very highly positive.
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