Amyloid-Beta 1-42 Cross-Reactive Antibody Prevalent in Human Sera May Contribute to Intraneuronal Deposition of A-Beta-P-42
Table 3
Correlations between IgG anti-AβP-42 antibody with IgG against other neuronal or associated proteins.
Variables
P values
Correlation coefficients
Amyloid β protein
0.0001
0.9680
Tau protein
0.0001
0.9497
α-synuclein
0.0001
0.9760
Presenilin
0.0001
0.7964
Adenosine triphosphate synthase
0.0001
0.4597
Rabaptin-5
0.0001
0.5892
S100B
0.0001
0.6892
Aquaporin-4
0.0001
0.8286
Claudin-5
0.0053
0.3361
Glial fibrillary acidic protein
0.0001
0.9286
Myelin basic protein
0.0001
0.4911
Asialoganglioside GM1
0.0146
0.2631
β-nerve growth factor
0.0001
0.8971
Brain-derived neurotrophic factor
0.0001
0.8743
Glutamate-Receptor
0.0112
0.2871
N-methyl-D-aspartate receptor
0.0129
0.2541
Dopamine receptors 1, 2
0.0616
0.1982
Glutamic acid decarboxylase 65
0.0173
0.2463
Transglutaminase-2
0.0001
0.4981
Transglutaminase-3
0.0001
0.6137
Microbial transglutaminase
0.0001
0.7792
Enteric neuronal antigen
0.0001
0.8963
We tested 22 variables for correlation and made a correction to the p value for multiple comparisons to avoid a false discovery rate, since, statistically, with an alpha value of 0.05, 1 out of 20 correlations would be a false positive. We used a Bonferroni correction by dividing the alpha by .05/22, resulting in a significant p value of 0.002.
