Alzheimer’s Disease Frontal Cortex Mitochondria Show a Loss of Individual Respiratory Proteins but Preservation of Respiratory Supercomplexes

<div><i>No relationships among subject ages and levels by immunoblotting of individual respiratory protein subunits.</i> Shown are relative levels of individual respiratory protein subunits, normalized to mitochondrial mass (VDAC/porin). SDHB= succinate dehydrogenase, subunit B (complex II); UQCRC2= ubiquinol-cytochrome c reductase core protein 2 (complex III); ATP5A = ATP synthase, subunit 5A (complex V); MT-CO2 = mitochondrial DNA-encoded cytochrome oxidase subunit 2 (complex IV); NDUFB8 = NADH: ubiquinone oxidoreductase subunit B8 (complex I). VDAC = voltage-dependent anion channel (abundant mitochondrial outer membrane protein).</div>

International Journal of Alzheimer’s Disease

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Figure 2: Alzheimer’s Disease Frontal Cortex Mitochondria Show a Loss of Individual Respiratory Proteins but Preservation of Respiratory Supercomplexes 

Figure 2 | Alzheimer’s Disease Frontal Cortex Mitochondria Show a Loss of Individual Respiratory Proteins but Preservation of Respiratory Supercomplexes 