International Journal of Alzheimer’s Disease

Genetics and Genomics of Late-Onset Alzheimer's Disease and Its Endophenotypes


Publishing date
01 Mar 2011
Status
Published
Submission deadline
01 Sep 2010

1G.H. Sergievsky Center, Taub Institute for Research on the Aging Brain and the Department of Neurology, Columbia University, New York, NY 10032, USA

2Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada M551A8

3Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA

4Departments of Medicine, Neurology, Genetics & Genomics, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA


Genetics and Genomics of Late-Onset Alzheimer's Disease and Its Endophenotypes

Description

Late-onset Alzheimer's disease (AD) is the most common cause of dementia in western societies. Despite remarkable advances in the past few years in the technologies available for human genetic studies, only a small proportion of the genetic contribution to AD has been identified. This leaves many remaining genetic risk factors still to be identified. There are several possible reasons for our failure to rapidly advance the field of AD genetics. First, AD is a multifactorial complex disorder with both genetic and environmental components. Second, multiple genes, each with small effects, are likely to contribute not only to AD susceptibility, but also to the quantitative traits associated with the disease (i.e., endophenotypes), including memory performance, amyloid/tau pathology, or hippocampal atrophy. Identifying the genetics underlying the variation in these endophenotypes could shed light on disease pathogenesis and would provide potential targets for effective treatment, screening, and prevention.

We invite investigators to submit original research and review articles that seek to elucidate the genetic factors contributing to the molecular pathologies underlying AD and its endophenotypes. We are particularly interested in articles that explore these factors in either humans or animal models of AD. We would also encourage manuscripts that focus on genetic, functional, translational, or bioinformatic approaches to gene identification.

Potential topics include, but are not limited to:

  • Genetic linkage and association studies of AD
  • Genetic studies employing CSF and blood biomarkers, imaging markers, or neuropsychological measures
  • Meta-analyses of existing genetic data
  • Gene-environment and gene-gene interactions in AD
  • Studies employing sequence analysis, structure analysis, or gene expression analysis
  • Studies employing bioinformatic and computational methods to identify genetic networks in AD
  • Epigenetics in AD
  • Pharmacogenomic or pharmacogenetic studies in AD
  • Results of animal models designed to identify novel genes contributing to AD or its related endophenotypes.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 284728
  • - Editorial

Genetics and Genomics of Late-Onset Alzheimer's Disease and Its Endophenotypes

Christiane Reitz | Ekaterina Rogaeva | ... | Lindsay A. Farrer
  • Special Issue
  • - Volume 2011
  • - Article ID 721457
  • - Review Article

Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene

Francesco Panza | Davide Seripa | ... | Alberto Pilotto
  • Special Issue
  • - Volume 2011
  • - Article ID 490140
  • - Review Article

Neuroimaging Measures as Endophenotypes in Alzheimer's Disease

Meredith N. Braskie | John M. Ringman | Paul M. Thompson
  • Special Issue
  • - Volume 2011
  • - Article ID 926597
  • - Research Article

Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E

Mary Ann A. DeMichele-Sweet | Oscar L. Lopez | Robert A. Sweet
  • Special Issue
  • - Volume 2011
  • - Article ID 729382
  • - Research Article

TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains

Sara Ansaloni | Brian P. Leung | ... | Aleister J. Saunders
  • Special Issue
  • - Volume 2011
  • - Article ID 929102
  • - Research Article

An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome

Emma L. Jones | Clive G. Ballard | ... | Maria Luisa Hanney
  • Special Issue
  • - Volume 2011
  • - Article ID 239453
  • - Research Article

AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5

Mithu Raychaudhuri | Debashis Mukhopadhyay
International Journal of Alzheimer’s Disease
 Journal metrics
Acceptance rate17%
Submission to final decision100 days
Acceptance to publication36 days
CiteScore3.800
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.