International Journal of Alzheimer’s Disease

Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013


Publishing date
22 Nov 2013
Status
Published
Submission deadline
05 Jul 2013

Lead Editor

1Department of Neuroscience, AFaR, Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy

2Department of Biology, University of Rome “Tor Vergata”, Rome, Italy

3Department of Neurology, University Hospital Utrecht, Utrecht, The Netherlands

4Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 5022 Kresge Building II, Ann Arbor, MI, USA

5Florey Institute of Neuroscience & Mental Health, University of Melbourne, Melbourne, VIC, Australia


Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013

Description

Alzheimer's disease (AD) is a leading cause of death worldwide. It is a genetically heterogeneous syndrome, which includes a broad spectrum of phenotypes. Recent advances in biology and medicine have introduced metals, particularly copper, as influencing agents in AD, thus improving understanding of the mechanisms and electrophysiology underlying the pathology. Increasing information has led to the development of new models or tools to characterize defective pathways of copper trafficking linked to neurodegenerative processes and the rational for phases II and III clinical trials as well.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying copper involvement in AD. Potential topics include, but are not limited to:

  • Advances in metal toxicity as well as genetics of AD
  • Latest technologies or strategies to point out metallobiological processes subtending typical deficits of AD
  • Role of inflammation related to copper status in AD
  • Metal-proteins interplay in AD, in mild cognitive impairment, and in other copper diseases of neurodegeneration other than AD
  • Recent advances in drug strategy based on metallobiology of AD as well as biological molecules, which induce or maintain a state of copper malabsorption
  • The increased toxicity of oral ingestion of inorganic copper (such as in drinking water or copper supplements) relative to organically bound copper in food
  • The interaction of lipids, for example, from a high fat diet, and copper in producing neurotoxicity
  • The interaction of lipids, for example, from a high fat diet, and copper in producing neurotoxicity
  • The mechanisms whereby aging increases susceptibility to copper toxicity in the brain

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ijad/cand13/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 838274
  • - Editorial

Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013

Rosanna Squitti | Tjaard Hoogenraad | ... | Renato Polimanti
  • Special Issue
  • - Volume 2013
  • - Article ID 638312
  • - Clinical Study

Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction: A MEG Study

C. Salustri | F. Tecchio | ... | R. Squitti
  • Special Issue
  • - Volume 2013
  • - Article ID 145345
  • - Review Article

Neuroinflammation and Copper in Alzheimer’s Disease

Xin Yi Choo | Lobna Alukaidey | ... | Alexandra Grubman
  • Special Issue
  • - Volume 2013
  • - Article ID 645379
  • - Research Article

Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration

Nathalie Arnal | Omar Castillo | ... | Carlos A. Marra
  • Special Issue
  • - Volume 2013
  • - Article ID 414817
  • - Research Article

Role of Copper and Cholesterol Association in the Neurodegenerative Process

Nathalie Arnal | Gustavo R. Morel | ... | Carlos A. Marra
  • Special Issue
  • - Volume 2013
  • - Article ID 623241
  • - Research Article

Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction

Alan Rembach | Dominic J. Hare | ... | Blaine R. Roberts
  • Special Issue
  • - Volume 2013
  • - Article ID 586365
  • - Review Article

Zinc Deficiency and Zinc Therapy Efficacy with Reduction of Serum Free Copper in Alzheimer’s Disease

George J. Brewer | Sukhvir Kaur
  • Special Issue
  • - Volume 2013
  • - Article ID 567128
  • - Research Article

Neuroprotective Role of a Novel Copper Chelator against Induced Neurotoxicity

Sandeep Kumar Singh | Priti Sinha | ... | S. Srikrishna
  • Special Issue
  • - Volume 2013
  • - Article ID 518780
  • - Review Article

Cholesterol and Copper Affect Learning and Memory in the Rabbit

Bernard G. Schreurs
International Journal of Alzheimer’s Disease
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