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Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013

Call for Papers

Alzheimer's disease (AD) is a leading cause of death worldwide. It is a genetically heterogeneous syndrome, which includes a broad spectrum of phenotypes. Recent advances in biology and medicine have introduced metals, particularly copper, as influencing agents in AD, thus improving understanding of the mechanisms and electrophysiology underlying the pathology. Increasing information has led to the development of new models or tools to characterize defective pathways of copper trafficking linked to neurodegenerative processes and the rational for phases II and III clinical trials as well.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying copper involvement in AD. Potential topics include, but are not limited to:

  • Advances in metal toxicity as well as genetics of AD
  • Latest technologies or strategies to point out metallobiological processes subtending typical deficits of AD
  • Role of inflammation related to copper status in AD
  • Metal-proteins interplay in AD, in mild cognitive impairment, and in other copper diseases of neurodegeneration other than AD
  • Recent advances in drug strategy based on metallobiology of AD as well as biological molecules, which induce or maintain a state of copper malabsorption
  • The increased toxicity of oral ingestion of inorganic copper (such as in drinking water or copper supplements) relative to organically bound copper in food
  • The interaction of lipids, for example, from a high fat diet, and copper in producing neurotoxicity
  • The interaction of lipids, for example, from a high fat diet, and copper in producing neurotoxicity
  • The mechanisms whereby aging increases susceptibility to copper toxicity in the brain

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 5 July 2013
First Round of ReviewsFriday, 27 September 2013
Publication DateFriday, 22 November 2013

Lead Guest Editor

  • Rosanna Squitti, Department of Neuroscience, AFaR, Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy

Guest Editors

  • Renato Polimanti, Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
  • Tjaard Hoogenraad, Department of Neurology, University Hospital Utrecht, Utrecht, The Netherlands
  • D. Larry Sparks, Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
  • George Brewer, Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 5022 Kresge Building II, Ann Arbor, MI, USA
  • Ashley I. Bush, Florey Institute of Neuroscience & Mental Health, University of Melbourne, Melbourne, VIC, Australia