International Journal of Alzheimer’s Disease

Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease


Publishing date
01 May 2011
Status
Published
Submission deadline
01 Nov 2010

Lead Editor

1Institute of Clinical Medicine – Neurology, University of Eastern Finland, 70211 Kuopio, Finland

2Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany

3Department of Biology, Drexel University, Philadelphia, PA, USA


Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease

Description

Alzheimer's disease (AD) is a complex disease, in which both genetic and environmental factors play an important role. Identification of these factors is a crucial task as it may provide new avenues to understand and design intervention approaches against AD. Recent progress in the genomics and particularly in the high-throughput genotyping technology has provided powerful tools to identify risk genes in complex diseases by employing, for example, genome-wide association (GWA) studies. Using the GWA as well as candidate gene approaches, several AD susceptibility genes with moderate risk effects have been identified from different ethnic populations. In most of the cases, however, biological relevance of the risk gene variations is still elusive, emphasizing the need for comprehensive functional characterization of these genes in AD pathogenesis. In addition, epidemiological and clinical studies have revealed that certain comorbidities, such as cerebral ischemia, traumatic brain injury (TBI), and type-2 diabetes (TD2), often precede or cooccur with AD and that they are affected by modifiable life-style factors. Collectively, detailed elucidation of the risk genes and comorbidities in the context of AD pathogenesis may lead to the identification of specific molecular targets underlying the clinical manifestation of AD.

We invite investigators to contribute original research articles and review articles that stimulate the efforts to identify novel molecular targets involved in AD pathogenesis. We are particularly interested in articles that address the current advances and concepts in AD genetics, new insights related to combined genetic and functional characterization of risk genes in AD, and effects of AD comorbidities (e.g., cerebral ischemia, TBI, and TD2) on measures relevant for AD pathogenesis, such as amyloid precursor protein processing, tau protein phosphorylation, as well as inflammation and oxidative stress. Potential topics include, but are not limited to:

  • Latest advances and concepts in AD genetics
  • Genetic and functional characterization of novel risk genes in AD
  • Role of comorbidities in AD pathogenesis
  • In vitro and in vivo models of AD comorbidities

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 925362
  • - Editorial

Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease

Mikko Hiltunen | Lars Bertram | Aleister J. Saunders
  • Special Issue
  • - Volume 2011
  • - Article ID 806293
  • - Review Article

Caloric Intake, Dietary Lifestyles, Macronutrient Composition, and Alzheimer’ Disease Dementia

Giulio Maria Pasinetti | Jun Wang | ... | Lap Ho
  • Special Issue
  • - Volume 2011
  • - Article ID 505984
  • - Research Article

Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936

Gillian Hamilton | Sarah E. Harris | ... | Ian J. Deary
  • Special Issue
  • - Volume 2011
  • - Article ID 312341
  • - Research Article

A Novel Study and Meta-Analysis of the Genetic Variation of the Serotonin Transporter Promoter in the Italian Population Do Not Support a Large Effect on Alzheimer's Disease Risk

Letizia Polito | Francesca Prato | ... | Diego Albani
  • Special Issue
  • - Volume 2011
  • - Article ID 312526
  • - Clinical Study

Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Ville Leinonen | Lata G. Menon | ... | Peter M. Black
  • Special Issue
  • - Volume 2011
  • - Article ID 576143
  • - Research Article

Lack of Association between the GPR3 Gene and the Risk for Alzheimer's Disease

Roberto Dominici | Marcello Ronchi | ... | Dario Finazzi
  • Special Issue
  • - Volume 2011
  • - Article ID 974361
  • - Review Article

Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease

Valérie Leduc | Dorothée Domenger | ... | Judes Poirier
  • Special Issue
  • - Volume 2011
  • - Article ID 726197
  • - Review Article

The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations

Elizabeth R. Tuminello | S. Duke Han
  • Special Issue
  • - Volume 2011
  • - Article ID 936580
  • - Research Article

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Elin S. Blom | Yijing Wang | ... | Martin Ingelsson
International Journal of Alzheimer’s Disease
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