Table of Contents
International Journal of Bacteriology
Volume 2013 (2013), Article ID 168179, 7 pages
http://dx.doi.org/10.1155/2013/168179
Research Article

Inflammatory Responses to Salmonella Infections Are Serotype-Specific

1Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia
2“Nork” Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia
3Faculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica

Received 23 April 2013; Revised 15 July 2013; Accepted 13 August 2013

Academic Editor: Christopher M. Parry

Copyright © 2013 Zhanna Ktsoyan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The main purpose of this study was to investigate the profile of inflammatory response in patients with acute salmonellosis caused by two serotypes of Salmonella enterica, S. Enteritidis and S. Typhimurium, as well as in convalescent patients with previous acute disease caused by S. Enteritidis. Patients with acute disease showed significantly elevated levels of IL-1β, IL-17, IL-10, and calprotectin compared to healthy control subjects. In convalescent patients, these markers were also significantly elevated, with the exception of IL-1β. Multivariate statistical analyses with the use of these variables produced models with a good predictive accuracy resulting in excellent separation of the diseased and healthy cohorts studied. Overall, the results suggest that the profile of inflammatory response in this disease is determined, to a significant degree, by the serotype of Salmonella, and the profile of certain cytokines and calprotectin remains abnormal for a number of months following the acute disease stage.