Table of Contents
International Journal of Bacteriology
Volume 2013 (2013), Article ID 512481, 5 pages
http://dx.doi.org/10.1155/2013/512481
Research Article

Decreased C3 Activation by the devR Gene-Disrupted Mycobacterium tuberculosis Strain in Comparison to the Wild-Type Strain

1Department of Clinical Pathology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre) (Indian Council of Medical Research), Mayor V. R. Ramanathan Road, Chetpet, Chennai, Tamil Nadu 600 031, India
2Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India

Received 31 December 2012; Revised 20 April 2013; Accepted 24 April 2013

Academic Editor: Doris Hillemann

Copyright © 2013 V. Narayan Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. D. Ramanathan, J. Curtis, and J. L. Turk, “Activation of the alternative pathway of complement by mycobacteria and cord factor,” Infection and Immunity, vol. 29, no. 1, pp. 30–35, 1980. View at Google Scholar · View at Scopus
  2. O. Parkash, V. D. Ramanathan, D. P. Singh, and U. Sengupta, “Activation of the alternative pathway of the complement system by mycobacteria,” Current Science, vol. 56, p. 968, 1987. View at Google Scholar
  3. O. Parkash, V. D. Ramanathan, D. P. Singh, and U. Sengupta, “Effect of anti-mycobacterial antibodies on activation of the alternative pathway of the human complement system,” FEMS Microbiology Letters, vol. 55, no. 3, pp. 255–258, 1988. View at Google Scholar · View at Scopus
  4. J. S. Ferguson, J. J. Weis, J. L. Martin, and L. S. Schlesinger, “Complement protein C3 binding to Mycobacterium tuberculosis is initiated by the classical pathway in human bronchoalveolar lavage fluid,” Infection and Immunity, vol. 72, no. 5, pp. 2564–2573, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Smith, “Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence,” Clinical Microbiology Reviews, vol. 16, no. 3, pp. 463–496, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. J. H. Lee, D. E. Geiman, and W. R. Bishai, “Role of stress response sigma factor SigG in Mycobactenum tuberculosis,” Journal of Bacteriology, vol. 190, no. 3, pp. 1128–1133, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Hu and A. R. M. Coates, “Mycobacterium tuberculosis acg gene is required for growth and virulence in vivo,” PLoS One, vol. 6, no. 6, Article ID e20958, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Rousseau, T. D. Sirakova, V. S. Dubey et al., “Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis,” Microbiology, vol. 149, no. 7, pp. 1837–1847, 2003. View at Google Scholar · View at Scopus
  9. V. Malhotra, D. Sharma, V. D. Ramanathan et al., “Disruption of response regulator gene,devR, leads to attenuation in virulence of Mycobacterium tuberculosis,” FEMS Microbiology Letters, vol. 231, no. 2, pp. 237–245, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. R. H. Pando, L. D. Aguilar, I. Smith, and R. Manganelli, “Immunogenicity and protection induced by a Mycobacterium tuberculosis sigE mutant in a BALB/c mouse model of progressive pulmonary tuberculosis,” Infection and Immunity, vol. 78, no. 7, pp. 3168–3176, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. H. D. Park, K. M. Guinn, M. I. Harrell et al., “Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis,” Molecular Microbiology, vol. 48, no. 3, pp. 833–843, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. I. Voskuil, D. Schnappinger, K. C. Visconti et al., “Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program,” Journal of Experimental Medicine, vol. 198, no. 5, pp. 705–713, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. N. K. Taneja, S. Dhingra, A. Mittal, M. Naresh, and J. S. Tyagi, “Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C,” PLoS One, vol. 5, no. 5, Article ID e10860, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Malhotra, J. S. Tyagi, and J. E. Clark-Curtiss, “DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism,” Tuberculosis, vol. 89, no. 2, pp. 169–174, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Parish, D. A. Smith, S. Kendall, N. Casali, G. J. Bancroft, and N. G. Stoker, “Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis,” Infection and Immunity, vol. 71, no. 3, pp. 1134–1140, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. S. D. Majumdar, D. Sharma, A. Vashist et al., “Co-expression of devR and DevRN-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis,” PLoS One, vol. 5, no. 2, Article ID e9448, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. L. S. Schlesinger, C. G. Bellinger-Kawahara, N. R. Payne, and M. A. Horwitz, “Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3,” Journal of Immunology, vol. 144, no. 7, pp. 2771–2780, 1990. View at Google Scholar · View at Scopus
  18. H. U. Schorlemmer, D. Bitter Suermann, and A. C. Allison, “Complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation,” Immunology, vol. 32, no. 6, pp. 929–940, 1977. View at Google Scholar · View at Scopus
  19. H. U. Schorlemmer, P. Davies, and A. C. Allison, “Ability of activated complement components to induce lysosomal enzyme release from macrophages,” Nature, vol. 261, no. 5555, pp. 48–49, 1976. View at Google Scholar · View at Scopus