Table of Contents
Letter to the Editor
International Journal of Bacteriology
Volume 2014, Article ID 418063, 6 pages
Research Article

Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region

1Laboratório de Patologia Clínica, Núcleo de Medicina Tropical, Universidade Federal do Pará, Avenida Generalissimo Deodoro No. 92, Umarizal, 66095-360 Belém, PA, Brazil
2Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doênças Tropicais, Universidade Federal do Pará, Belém, PA, Brazil
3Departamento de Gastroenterologia, Hospital Ophir Loyola, Belém, PA, Brazil

Received 30 December 2013; Accepted 7 April 2014; Published 24 April 2014

Academic Editor: Rodrigo E. Mendes

Copyright © 2014 Adenielson Vilar e Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Helicobacter pylori is associated with the development of different diseases. The clinical outcome of infection may be associated with the cagA bacterial genotype. The aim of this study was to determine the EPIYA patterns of strains isolated from patients with gastritis and gastric adenocarcinoma and correlate these patterns with the histopathological features. Gastric biopsy samples were selected from 384 patients infected with H. pylori, including 194 with chronic gastritis and 190 with gastric adenocarcinoma. The presence of the cagA gene and the EPIYA motif was determined by PCR. The cagA gene was more prevalent in patients with gastric cancer and was associated with a higher degree of inflammation, neutrophil activity, and development of intestinal metaplasia. The number of EPIYA-C repeats showed a significant association with an increased risk of gastric carcinoma (OR = 3.79, 95% CI = 1.92–7.46, and ). A larger number of EPIYA-C motifs were also associated with intestinal metaplasia. In the present study, infection with H. pylori strains harboring more than one EPIYA-C motif in the cagA gene was associated with the development of intestinal metaplasia and gastric adenocarcinoma but not with neutrophil activity or degree of inflammation.