A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis: Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy

Table 7

Comparison of mean Ki67 indices in molecular subtypes of pDCIS and IBCA.

subtypes	Ki67	Ki67	𝑃 value
	DCIS	IBCA
LUMINAL-A	6.98 ± 0.52 (𝑛=44)	7.05 ± 0.75 (𝑛=21)	𝑃>0.05
LUMINAL-B	23.8 ± 2.22 (𝑛=31)	33.76 ± 2.53 (𝑛=30)	𝑃>0.05
LUM-HER2	23.27 ± 2.72 (𝑛=22)	41.67 ± 6.50 (𝑛=15)	𝑃<0.01
HER2	33.57 ± 4.87 (𝑛=14)	58.00 ± 9.46 (𝑛=8)	𝑃<0.01
TRIPLE NEG	39.57 ± 13.64 (𝑛=7)	67.52 ± 6.04 (𝑛=26)	𝑃<0.01

* 𝑃 value calculated by two-way ANOVA followed by Bonferroni post hoc test.