17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats
Figure 2
Tumor volume in response to treatment. Seven-week-old female Lewis rats were treated with a single IP injection of 50 mg/kg MNU. Tumors developed for 90 days, prior to treatment () for 28 days with (1) cyclodextrin vehicle daily, (2) 6.6 mg HE3235 daily, (3) 4 mg HE3235 daily, (4) 6.6 mg HE3235 daily + 1.5 mg docetaxel weekly, (5) 1.5 mg docetaxel weekly, (6) 2.5 mg anastrazole daily, and (7) 0.25 mg tamoxifen weekly. HE3235 in combination with docetaxel was more effective than comparator monotherapies at decreasing the mean tumor volume per animal. Upper graph, all results plotted full scale; lower graph, split and expanded -axis. Anastrazole results were similar to docetaxel, but not plotted to improve clarity. The mean tumor volume for vehicle on day 101 was 0.41 cm3, which was not plotted to improve clarity. Tax, docetaxel, Tam, tamoxifen.
