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International Journal of Breast Cancer
Volume 2012, Article ID 171792, 16 pages
http://dx.doi.org/10.1155/2012/171792
Review Article

Imaging-Assisted Large-Format Breast Pathology: Program Rationale and Development in a Nonprofit Health System in the United States

Virginia Biomedical Laboratories, LLC, P.O. Box 510, Wirtz, VA 24184, USA

Received 13 July 2012; Accepted 10 October 2012

Academic Editor: Tibor Tot

Copyright © 2012 F. Lee Tucker. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. W. Duffy, L. Tabár, H. H. Chen et al., “The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish Counties: a collaborative evaluation,” Cancer, vol. 95, no. 3, pp. 458–469, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. S. W. Duffy, “Reduction in breast cancer mortality from organized service screening with mammography—1. Further confirmation with extended data,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 1, pp. 45–51, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Tabar, M. F. Yen, B. Vitak, H. H. Tony Chen, R. A. Smith, and S. W. Duffy, “Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening,” Lancet, vol. 361, no. 9367, pp. 1405–1410, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. N. G. Coburn, M. A. Chung, J. Fulton, and B. Cady, “Decreased breast cancer tumor size, stage, and mortality in Rhode Island: an example of a well-screened population,” Cancer Control, vol. 11, no. 4, pp. 222–230, 2004. View at Google Scholar · View at Scopus
  5. L. Tabár, R. A. Smith, B. Vitak et al., “Mammographic screening: a key factor in the control of breast cancer,” Cancer Journal, vol. 9, no. 1, pp. 15–27, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Morrow, R. A. Schmidt, and C. Bucci, “Breast conservation for mammographically occult carcinoma,” Annals of Surgery, vol. 227, no. 4, pp. 502–506, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Fitzal and M. Gnant, “Breast conservation: evolution of surgical strategies,” Breast Journal, vol. 12, no. 2, supplement, pp. S165–S173, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Fisher, M. Bauer, and R. Margolese, “Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer,” New England Journal of Medicine, vol. 312, no. 11, pp. 665–673, 1985. View at Google Scholar · View at Scopus
  9. B. Fisher, S. Anderson, J. Bryant et al., “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” New England Journal of Medicine, vol. 347, no. 16, pp. 1233–1241, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Bijker, P. Meijnen, J. L. Peterse et al., “Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of european organisation for research and treatment of cancer randomized phase III trial 10853—a study by the EORTC breast cancer cooperative group and EORTC radiotherapy group,” Journal of Clinical Oncology, vol. 24, no. 21, pp. 3381–3387, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. G. P. Swanson, K. Rynearson, and R. Symmonds, “Significance of margins of excision on breast cancer recurrence,” American Journal of Clinical Oncology, vol. 25, no. 5, pp. 438–441, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. C. D. Scopa, P. Aroukatos, A. C. Tsamandas, and C. Aletra, “Evaluation of margin status in lumpectomy specimens and residual breast carcinoma,” Breast Journal, vol. 12, no. 2, pp. 150–153, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. F. Dillon, A. D. K. Hill, C. M. Quinn, E. W. McDermott, and N. O'Higgins, “A pathologic assessment of adequate margin status in breast-conserving therapy,” Annals of Surgical Oncology, vol. 13, no. 3, pp. 333–339, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. S. DiBiase, L. Komarnicky, and G. Schwartz, “The number of positive margins influences the outcome of women treated with breast preservation for early stage breast carcinoma,” Cancer, vol. 82, no. 11, pp. 2212–2220, 1998. View at Google Scholar
  15. S. Schnitt, A. Abner, and R. Gelman, “The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy,” Cancer, vol. 74, no. 6, pp. 1746–1751, 1994. View at Google Scholar
  16. R. Holland, J. L. Connolly, R. Gelman et al., “The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast,” Journal of Clinical Oncology, vol. 8, no. 1, pp. 113–118, 1990. View at Google Scholar · View at Scopus
  17. M. S. Anscher, P. Jones, L. R. Prosnitz et al., “Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy,” Annals of Surgery, vol. 218, no. 1, pp. 22–28, 1993. View at Google Scholar · View at Scopus
  18. B. Spivack, M. M. Khanna, L. Tafra et al., “Margin status and local recurrence after breast-conserving surgery,” Archives of Surgery, vol. 129, no. 9, pp. 952–957, 1994. View at Google Scholar · View at Scopus
  19. C. Kunos, L. Latson, B. Overmoyer et al., “Breast conservation surgery achieving ≥2 mm tumor-free margins results in decreased local-regional recurrence rates,” Breast Journal, vol. 12, no. 1, pp. 28–36, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Cheng, N. K. Al-Kaisi, N. H. Gordon, A. Y. Liu, F. Gebrail, and R. R. Shenk, “Relationship between the size and margin status of ductal carcinoma in situ of the breast and residual disease,” Journal of the National Cancer Institute, vol. 89, no. 18, pp. 1356–1360, 1997. View at Google Scholar · View at Scopus
  21. H. R. Macdonald, M. J. Silverstein, L. A. Lee et al., “Margin width as the sole determinant of local recurrence after breast conservation in patients with ductal carcinoma in situ of the breast,” American Journal of Surgery, vol. 192, no. 4, pp. 420–422, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Silverstein, E. Gierson, and W. Colburn, “Can intraductal breast carcinoma be excised completely by local excision?” Cancer, vol. 73, no. 12, pp. 2985–2989, 1994. View at Google Scholar
  23. H. R. MacDonald, M. J. Silverstein, H. Mabry et al., “Local control in ductal carcinoma in situ treated by excision alone: incremental benefit of larger margins,” American Journal of Surgery, vol. 190, no. 4, pp. 521–525, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. P. A. Holland, A. Gandhi, W. F. Knox, M. Wilson, A. D. Baildam, and N. J. Bundred, “The importance of complete excision in the prevention of local recurrence of ductal carcinoma in situ,” British Journal of Cancer, vol. 77, no. 1, pp. 110–114, 1998. View at Google Scholar · View at Scopus
  25. K. Chan, W. Knox, G. Sinha et al., “Extent of excision margin width required in breast conserving surgery for ductal carcinoma in situ,” Cancer, vol. 91, no. 1, pp. 9–16, 2001. View at Google Scholar
  26. A. G. Douglas-Jones, J. Logan, J. M. Morgan, R. Johnson, and R. Williams, “Effect of margins of excision on recurrence after local excision of ductal carcinoma in situ of the breast,” Journal of Clinical Pathology, vol. 55, no. 8, pp. 581–586, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. A. C. Neuschatz, T. DiPetrillo, M. Steinhoff et al., “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer, vol. 94, no. 7, pp. 1917–1924, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. P. S. Mullenix, D. G. Cuadrado, S. R. Steele et al., “Secondary operations are frequently required to complete the surgical phase of therapy in the era of breast conservation and sentinel lymph node biopsy,” American Journal of Surgery, vol. 187, no. 5, pp. 643–646, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. N. Rodriguez, L. K. Diaz, and E. L. Wiley, “Predictors of residual disease in repeat excisions for lumpectomies with margins less than 0.1 cm,” Clinical Breast Cancer, vol. 6, no. 2, pp. 169–172, 2005. View at Google Scholar · View at Scopus
  30. S. G. MacAusland, J. T. Hepel, F. K. Chong et al., “An attempt to independently verify the utility of the Van Nuys Prognostic Index for ductal carcinoma in situ,” Cancer, vol. 110, no. 12, pp. 2648–2653, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. F. L. Tucker, “New era pathologic techniques in the diagnosis and reporting of breast cancers,” Seminars in Breast Disease, vol. 11, no. 3, pp. 140–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. I. D. Campbell, J. M. Theaker, G. T. Royle et al., “Impact of an extensive in situ component on the presence of residual disease in screen detected breast cancer,” Journal of the Royal Society of Medicine, vol. 84, no. 11, pp. 652–656, 1991. View at Google Scholar · View at Scopus
  33. T. Tot, L. Tabár, and P. B. Dean, “The pressing need for better histologic-mammographic correlation of the many variations in normal breast anatomy,” Virchows Archiv, vol. 437, no. 4, pp. 338–344, 2000. View at Google Scholar · View at Scopus
  34. S. Lester, S. Bose, and Y. Chen, “Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast,” Archives of Pathology and Laboratory Medicine, vol. 133, pp. 15–24, 2009. View at Google Scholar
  35. A. Grin, G. Horne, M. Ennis, and F. P. O'Malley, “Measuring extent of ductal carcinoma in situ in breast excision specimens,” Archives of Pathology and Laboratory Medicine, vol. 133, no. 1, pp. 31–37, 2009. View at Google Scholar · View at Scopus
  36. F. Dadmanesh, X. Fan, A. Dastane, M. B. Amin, and S. Bose, “Comparative analysis of size estimation by mapping and counting number of blocks with ductal carcinoma in situ in breast excision specimens,” Archives of Pathology and Laboratory Medicine, vol. 133, no. 1, pp. 26–30, 2009. View at Google Scholar · View at Scopus
  37. M. F. Dillon, E. W. Mc Dermott, A. O'Doherty, C. M. Quinn, A. D. Hill, and N. O'Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Annals of Surgical Oncology, vol. 14, no. 5, pp. 1618–1628, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. J. H. Menell, E. A. Morris, D. D. Dershaw, A. F. Abramson, E. Brogi, and L. Liberman, “Determination of the presence and extent of pure ductal carcinoma in situ by mammography and magnetic resonance imaging,” Breast Journal, vol. 11, no. 6, pp. 382–390, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Holland, S. H. J. Veling, M. Mravunac, and J. H. C. L. Hendriks, “Histologic multifocality of Tis, T1-2 breast carcinomas: implications for clinical trials of breast-conserving surgery,” Cancer, vol. 56, no. 5, pp. 979–990, 1985. View at Google Scholar · View at Scopus
  40. T. Kato, T. Kimura, N. Ishii et al., “Pathologic evaluation of surgical margins and local recurrences after breast-conserving surgery without irradiation,” World Journal of Surgery, vol. 24, no. 3, pp. 328–333, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Sigal-Zafrani, J. S. Lewis, K. B. Clough et al., “Histological margin assessment for breast ductal carcinoma in situ: precision and implications,” Modern Pathology, vol. 17, no. 1, pp. 81–88, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. K. T. Mai, D. G. Perkins, and D. Mirsky, “Location and extent of positive resection margins and ductal carcinoma in situ in lumpectomy specimens of ductal breast carcinoma examined with a microscopic three-dimensional view,” Breast Journal, vol. 9, no. 1, pp. 33–38, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Ichihara, H. Suzuki, M. Kasami et al., “A new method of margin evaluation in breast conservation surgery using an adjustable mould during fixation,” Histopathology, vol. 39, no. 1, pp. 85–92, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. W. A. Berg, L. Gutierrez, M. S. NessAiver et al., “Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer,” Radiology, vol. 233, no. 3, pp. 830–849, 2004. View at Google Scholar · View at Scopus
  45. A. P. Schouten van der Velden, C. Boetes, P. Bult, and T. Wobbes, “The value of magnetic resonance imaging in diagnosis and size assessment of in situ and small invasive breast carcinoma,” American Journal of Surgery, vol. 192, no. 2, pp. 172–178, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Chung, R. Saouaf, K. Scharre, and E. Phillips, “The impact of MRI on the treatment of DCIS,” American Surgeon, vol. 71, no. 9, pp. 705–710, 2005. View at Google Scholar · View at Scopus
  47. N. Houssami, S. Ciatto, P. Macaskill et al., “Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer,” Journal of Clinical Oncology, vol. 26, no. 19, pp. 3248–3258, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. L. J. Solin, “Counterview: pre-operative breast MRI (magnetic resonance imaging) is not recommended for all patients with newly diagnosed breast cancer,” Breast, vol. 19, no. 1, pp. 7–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. T. Tot, L. Tabar, and P. Dean, Practical Breast Pathology, Thieme, New York, NY, USA, 2002.
  50. T. Tot, “Clinical relevance of the distribution of the lesions in 500 consecutive breast cancer cases documented in large-format histologic sections,” Cancer, vol. 110, no. 11, pp. 2551–2560, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. S. R. Wellings, H. M. Jensen, and R. G. Marcum, “An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions,” Journal of the National Cancer Institute, vol. 55, no. 2, pp. 231–273, 1975. View at Google Scholar · View at Scopus
  52. P. A. Jackson, W. Merchant, C. J. McCormick, and M. G. Cook, “A comparison of large block macrosectioning and conventional techniques in breast pathology,” Virchows Archiv, vol. 425, no. 3, pp. 243–248, 1994. View at Google Scholar · View at Scopus
  53. M. P. Foschini, F. Flamminio, R. Miglio et al., “The impact of large sections on the study of in situ and invasive duct carcinoma of the breast,” Human Pathology, vol. 38, no. 12, pp. 1736–1743, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. M. P. Foschini, A. Righi, M. C. Cucchi et al., “The impact of large sections and 3D technique on the study of lobular in situ and invasive carcinoma of the breast,” Virchows Archiv, vol. 448, no. 3, pp. 256–261, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. K. W. Biesemier and M. C. Alexander, “Enhancement of mammographic-pathologic correlation utilizing large format histology for malignant breast disease,” Seminars in Breast Disease, vol. 8, no. 3, pp. 152–162, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Méchine-Neuville, M. P. Chenard, B. Gairard, C. Mathelin, and J. P. Bellocq, “Large section technique in breast pathology an appropriate response to breast-conserving surgery,” Annales de Pathologie, vol. 20, no. 3, pp. 275–279, 2000. View at Google Scholar · View at Scopus
  57. M. Silverstein, A. Recht, and S. Harms, “Image-detected breast cancer: state of the art diagnosis and treatment,” Journal of the American College of Surgeons, vol. 201, no. 4, pp. 586–597, 2005. View at Google Scholar
  58. M. Idowu, L. Hardy, R. Souers et al., “Pathologic diagnostic correlation with breast imaging findings. A college of american pathologists Q-probes study of 48 institutions,” Archives of Pathology and Laboratory Medicine, vol. 136, pp. 53–60, 2012. View at Google Scholar