The Role of Large-Format Histopathology in Assessing Subgross Morphological Prognostic Parameters: A Single Institution Report of 1000 Consecutive Breast Cancer Cases

Figure 2

Schematic illustration of the possible combined growth patterns in breast carcinomas. (a) Unifocal in situ component, no invasive component. (b) Multifocal in situ component, no invasive component. (c) Diffuse in situ component, no invasive component. (d) Unifocal invasive component, no in situ component. (e) Unifocal invasive component, unifocal in situ component within the area of the invasive focus, and unifocal combined pattern. (f) Unifocal invasive component, multifocal in situ component, and multifocal combined pattern. (g) Unifocal invasive component, diffuse in situ component, and diffuse combined pattern. (h) Multifocal invasive component, no in situ component. (i) Multifocal invasive component, unifocal in situ component in one of the invasive foci, and multifocal combined pattern. (j) Multifocal invasive component, multifocal in situ component, and multifocal combined pattern. (k) Multifocal invasive component, diffuse in situ component, and diffuse combined pattern. (l) Diffuse invasive component, no in situ component. (m) Diffuse invasive component, unifocal in situ component, and diffuse combined pattern. (n) Diffuse invasive component, multifocal in situ component, and diffuse combined pattern. (o) Diffuse invasive component, diffuse in situ component, and diffuse combined pattern. (p) Unifocal invasive component, unifocal in situ component outside the invasive focus, and multifocal combined pattern. (q) Drawing illustrating one of the possible mixed patterns with both diffusely growing and well-delineated invasive foci, with a diffuse combined pattern. The upper right image illustrates the sick lobe. Numbers in the lower left corner of the drawings indicate the number of cases in the series of 1000 consecutive breast carcinomas belonging to that category.